Download Advances in Molecular and Cellular Endocrinology, Vol. 2 by Derek LeRoith PDF

By Derek LeRoith

ISBN-10: 0762302925

ISBN-13: 9780762302925

Quantity 2 has thinking about points of the pituitary gland either anterior (growth hormone and prolactin receptors, and GH motion) and posterior (vasopressin) pituitary. additionally, thyroid melanoma and steroidogenic enzymes and precocious puberty are coated. ultimately, the "hot themes" contain leptin and progress issue signaling.

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Chem. 269, 14021-14026. A. (1995a). A single phosphotyrosine residue of the prolactin receptor is responsible for activation of gene transcription. Proc. Natl. Acad. Sci. USA 92, 4031-4035. A. (1995b). Proline-rich sequence-mediated JAK2 association to the prolactin receptor is required but not sufficient for signal transduction. J. Biol. Chem. 270, 10664-10670. , & Djiane, J. (1993). Roles of the extracellular and cytoplasmic domains of the prolactin receptor in signal transduction to milk protein genes.

Chem. 270, 21326-21330. , & Horn, F. (1996). Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp 130. II. Src homology SH2 domains define specificity of stat factor activation. J. Biol. Chem. 271, 12999-13007. F. (1996). Saturation mutagenesis of the WSXWS motifofthe erythropoietin receptor. J. Biol. Chem. 271, 4699-4708. E. (1993). Expression of the extracellular domain of the rat liver prolactin receptor and its interaction with ovine prolactin.

Sci. USA 93, 1-6. A. (1995). Mediation of growth hormone-dependent transcriptional activation by mammary gland factor/STAT5. J. Biol. Chem. 270, 9448-9453. This Page Intentionally Left Blank Chapter 2 Molecular Aspects of Growth Hormone Action MICHAEL J. THOMAS and PETER ROTWEIN Introduction Growth Hormone: Structure Growth Hormone Receptor Structure and Expression Ligand Binding and Dimerization Growth Hormone Receptor Signaling Activation of JAK2 Phosphorylation and Activation of Intracellular Proteins Activation of STATs Activation of Gene Expression by Growth Hormone Growth Hormone Receptor Internalization and Translocation to the Nucleus Other Signal Transduction Pathways Activated by Growth Hormone Specificity of Signaling by the Growth Hormone Receptor Summary Acknowledgments Advances in Molecular and Cellular Endocrinology Volume 2, pages 35-57.

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Advances in Molecular and Cellular Endocrinology, Vol. 2 by Derek LeRoith

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