Download Advances in Chromatographic Techniques for Therapeutic Drug by Amitava Dasgupta PDF

By Amitava Dasgupta

ISBN-10: 1420067583

ISBN-13: 9781420067583

For medicinal drugs with a slim healing index, healing drug tracking tools are crucial for sufferer administration. even though immunoassays are commercially to be had for lots of medicines and so much laboratories use those assays for regimen healing tracking, they've got many obstacles which prevent their efficacy. offering functional guidance for imposing most well liked fuel and liquid chromatographic equipment, Advances in Chromatographic innovations for healing Drug tracking is a finished reference describing the speculation and alertness of healing drug tracking in scientific laboratories. Edited by way of a extraordinary authority within the box and containing contributions from various specialists, the publication discusses preanalytical variables, the pitfalls of immunoassays, tandem mass spectrometry, matters regarding discomfort administration and natural supplementations, and healing drug tracking for a number of medicinal drugs, together with: Anticonvulsants Digitalis Cardioactive medications Antidepressants Immunosuppressants Anti-cancer medications Vancomycin and aminoglycosides Antibiotics Antiretroviral medications Nonnarcotic analgesics anti inflammatory medications ? Examing older and more recent medications, the e-book comprises specific discussions at the reason for healing drug tracking of every category of substances, in addition to their uncomplicated pharmacology and toxicology. an in depth record of references is supplied on the finish of every bankruptcy in order that these attracted to imposing a brand new drug assay can locate the main acceptable approach for the meant drug.

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Erythromycin may increase blood concentration of alcohol by accelerating gastric emptying [83]. Histamine H2 receptor antagonists, such as cimetidine, ranitidine, nizatidine and famotidine reduce the activity of alcohol dehydrogenase [84]. Alcohol increases the sedative effect of tricyclic antidepressants through pharmacodynamic interactions. In addition, alcohol can also cause pharmacokinetic interactions. Alcohol appears to interfere with first pass metabolism of amitriptyline, thus, increasing serum levels of this drug.

Generally, boiling point increases with increasing polarity. This causes compounds with low polarity to elute faster than the compounds with high polarity. Compounds are typically identified by the retention time (RT) or travel time needed to pass through the GC column. After separation by GC, compounds can be detected by flameionization detector (FID), electron-capture detector (ECD), nitrogen–phosphorus detector (NPD), or other electrochemical detectors. Although ECD and NPD are specific to some of the functions of the compounds, none of the detectors are compound specific.

In addition, the presence of high bilirubin in the serum or plasma, high lipid concentration, hemolysis and variety of other factors may significantly alter true concentration of a drug measured by immunoassays (see also Chapter 3 for detail). Therefore, despite advances in immunoassay techniques for therapeutic drug monitoring, chromatographic techniques play an important role in analytical measurement of concentrations of many drugs in clinical laboratories. Moreover, no immunoassay is commercially available for more recently approved drugs, also many other drugs require monitoring and for these drugs chromatographic techniques are the only choice.

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Advances in Chromatographic Techniques for Therapeutic Drug Monitoring by Amitava Dasgupta


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