Download Adrenal Toxicology by Philip W. Harvey, David J. Everett, Christopher J. Springall PDF

By Philip W. Harvey, David J. Everett, Christopher J. Springall

ISBN-10: 1420061291

ISBN-13: 9781420061291

Despite being considered as the most typical toxicological aim within the endocrine approach, the adrenal gland has usually been overlooked in regulatory trying out. Adrenal Toxicology addresses the elevated curiosity in adrenocortical toxicology and the necessity for a source that makes recommendations on hand to envision adrenal endocrine disruption.

Examining present concepts and the newest developments, Adrenal Toxicology studies the endocrinology, pharmacology, pathology and toxicology of the adrenal gland. this article presents info at the diversity of gear and chemical substances that impact adrenocortical functionality and indicates standardized techniques for in vivo and in vitro review. This quantity additionally offers fresh advancements within the molecular mechanisms of toxicity to the adrenal cortex and medulla, and considers environmental adrenal endocrine disruption in sentinel species.

Adrenal Toxicology :

  • reflects the key advancements remodeled the earlier decade
  • focuses at the newest study innovations, together with their makes use of and limitations
  • provides an built-in procedure for adrenal toxicology evaluation
  • identifies wisdom and information gaps, supplying impetus for regulatory consideration

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Additional resources for Adrenal Toxicology

Sample text

Epidermal growth factor increases cortisol production and type II 3 beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4)-isomerase expression in human adrenocortical carcinoma cells: evidence for a Stat5-dependent mechanism. Endocrinology 2003; 144:1847–1853. Florio S, Ciarcia R, Crispino L, et al. Hydrocortisone has a protective effect on cyclosporin A-induced cardiotoxicity. J Cell Physiol 2003; 195:21–26. Frank GR, Speiser PW, Griffin KJ, Safety of medications and hormones used in pediatric endocrinology: Adrenal.

Glucocorticoids: Deleterious effects on neurons and potential exacerbation of environmental toxicity. In: Harvey PW, ed. The Adrenal in Toxicology: Target Organ and Modulator of Toxicity. London: Taylor & Francis, 1996:205–221. Mercado–Asis LB, Yanovski JA, Tracer HL, et al. Acute effects of bromocriptine, cyproheptadine and valproic acid on plasma adrenocorticotropin secretion in Nelson’s syndrome. J Clin Endocrinol Metab 1997; 82:514–517. Metzeler K, Agonston A, Gratzl M. An intrinsic gamma-aminobutyric acid (GABA)ergic system in the adrenal cortex: Findings from human and rat adrenal glands and the NCI-H295R cell line.

Chichester: John Wiley,; 1999:291– 307. Hecker M, Giesy JP. Novel trends in endocrine disruptor testing: The H295R steroidogenesis assay for identification of inducers and inhibitors of hormone production. Anal Bioanal Chem 2007. Hecker M, Newsted JL, Murphy MB, et al. Human adrenocarcinoma (H295R) cells for rapid in vitro determination of effects on steroidogenesis: Hormone production. Toxicol Appl Pharmacol 2006; 217:114–124. Hecker M, Hollert H, Cooper R, et al. The OECD validation program of the H295R steroidogenesis assay for the identification of in vitro inhibitors and inducers of testosterone and estradiol production.

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Adrenal Toxicology by Philip W. Harvey, David J. Everett, Christopher J. Springall


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