Download A Synopsis of Endocrinology and Metabolism by David G. Ferriman PDF

By David G. Ferriman

ISBN-10: 0723602050

ISBN-13: 9780723602057

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Failure of development is often associated with maldescent, so t h a t the thyroid remnant may be found anywhere in the midline from a relatively normal position to the root of the tongue. —The degree of hypothyroidism present will depend upon the size of the thyroid remnant. —Complete absence of the thyroid will be associated with absence of 131 I uptake. Thyroid remnants may be associated with high suppressible uptakes and a high 48-hour PBI 1 3 1 . 2. —Inherited enzyme or related defects in synthesis of thyroxine.

Propyl thiouracil is a good substitute if sensitivity reaction to carbimazole develops; initial dose 200 mg. s. Treatment should be continued for 1-2 years. Some authorities favour combining the use of antithyroid drug with thyroxine. It is possible to achieve a finer control with this technique and it may be of particular value in juvenile hyperthyroidism and severe or malignant exophthalmos. c. —Dosage is based upon an estimate of goitre size and percentage uptake of iodine by thyroid. The former is unreliable, and an unknown quantity exists—the varying sensitivity of individual glands to radiation.

Hypotension, croaky voice, muscular rigidity. Extensor plantar reflexes. G. changes: prolonged QRS, inverted T waves, J wave at junction of QRS and S-T segments in chest leads. — 1. Cover with blanket and nurse in warm room. Active rewarming is dangerous. 2. Tri-iodothyronine is given for rapid effect but in small doses (5 μg. intravenously at 8-hour intervals). Cardiac muscle is affected by myxoedematous change and indirectly by grossly atheromatous coronary arteries. Larger doses of T3 may precipitate acute cardiac failure and death.

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A Synopsis of Endocrinology and Metabolism by David G. Ferriman


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